Dr. Shu-Ting Yang
Dr. Yang graduated from the Xiangya School of Pharmacy, Central South University, and is currently an expert member of the Technology Center at Geneham Pharmaceutical Co., Ltd. Her expertise spans a variety of molecular biology and biotechnology techniques, including: gene cloning, site-directed mutagenesis, CRISPR-Cas9, prokaryotic protein expression and purification, FRAP, droplet formation, kinase assays, lentiviral preparation, transfection, and the construction of stable cell lines for knockout and overexpression studies. To date, she has authored four articles in internationally renowned scientific journals.
Hosted and participated in scientific research projects:
1. Study on Structure Modification, Structure Activity Relationship and Anti breast cancer Mechanism of Natural Selective Estrogen Receptor Modulator VB1
2 Research on The Preparation of PDE4B and VB-6 Cocrystals
3. Research on The Effect of polyP and phase separation on cells
4. Research on the mechanism of anti-atherosclerosis effect of DFMG mediated by TLR4 signaling pathway
Papers published in the past five years:
[1] Yang, S.T. , Zeng, G.Y., Zhu, G.H., Zhou, T.S., Zhou, Y.J. . VB-10F1 inhibit TNFα and IFNγ Triggers Inflammatory Cell Death through target PDE4B.（The results are patent pending, manuscipt in preparation）
[2]Yang, S. T., Fan, J. B., Liu, T. T., Ning, S., Xu, J. H., Zhou, Y. J., & Deng, X. (2022). Development of Strigolactones as Novel Autophagy/Mitophagy Inhibitors against Colorectal Cancer Cells by Blocking the Autophagosome-Lysosome Fusion[J]. Journal of medicinal chemistry. 2022, 65, 14, 9706–9717.
[3] Cao, W., Liu, T., Yang, S., Liu, M., Pan, Z., Zhou, Y., & Deng, X. (2021). Efficient Synthesis of Icetexane Diterpenes and Apoptosis Inducing Effect by Upregulating BiP-ATF4-CHOP Axis in Colorectal Cells[J]. Journal of natural products, 84(7), 2012–2019.
[4] Cong, L., Yang, S., Zhang, Y., Cao, J., & Fu, X. (2018). DFMG attenuates the activation of macrophages induced by co culture with LPC injured HUVE 12 cells via the TLR4/MyD88/NF κB signaling pathway[J]. International journal of molecular medicine, 41(5), 2619–2628.
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